The C-514T polymorphism in the human hepatic lipase gene promoter diminishes its activity
نویسندگان
چکیده
منابع مشابه
The C-514T polymorphism in the human hepatic lipase gene promoter diminishes its activity.
Four common polymorphisms in the promoter of the hepatic lipase gene (LIPC) that are in almost complete linkage disequilibrium have been described in different ethnic groups. The T and A alleles at positions -514 and -250, respectively, were observed to be associated with decreased hepatic lipase (HL) activity and increased triglyceride content of HDL and LDL particles. We investigated whether ...
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15 صفحه اولA hepatic lipase gene promoter polymorphism attenuates the increase in hepatic lipase activity with increasing intra-abdominal fat in women.
High hepatic lipase (HL) activity is associated with an atherogenic lipoprotein profile of small, dense LDL particles and lower HDL(2)-C. Intra-abdominal fat (IAF) is positively associated with HL activity. A hepatic lipase gene (LIPC) promoter variant (G-->A(-250)) is associated with lower HL activity, higher HDL(2)-C, and less dense LDL particles. To determine whether the LIPC promoter polymo...
متن کاملLipase Activity With Increasing Intra-abdominal Fat in Women A Hepatic Lipase Gene Promoter Polymorphism Attenuates the Increase in Hepatic
High hepatic lipase (HL) activity is associated with an atherogenic lipoprotein profile of small, dense LDL particles and lower HDL2-C. Intra-abdominal fat (IAF) is positively associated with HL activity. A hepatic lipase gene (LIPC) promoter variant (G3A) is associated with lower HL activity, higher HDL2-C, and less dense LDL particles. To determine whether the LIPC promoter polymorphism acts ...
متن کاملTranscriptional regulation of the human hepatic lipase (LIPC) gene promoter.
Hepatic lipase (HL) plays a key role in the metabolism of plasma lipoproteins, and its level of activity requires tight regulation, given the association of both low and high levels with atherosclerosis and coronary artery disease. However, little is known about the factors responsible for HL expression. Here, we report that the human hepatic lipase gene (LIPC) promoter is regulated by hepatocy...
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ژورنال
عنوان ژورنال: Journal of Lipid Research
سال: 2000
ISSN: 0022-2275
DOI: 10.1016/s0022-2275(20)32086-1